GHRP-2 (Pralmorelin)

Published · Researched 2026-09-21

Research file — dated 2026-09-20. Research documentation only; not medical advice.

Overview — maker/originator, what it is, current 2026 status

GHRP-2 (growth hormone-releasing peptide-2), INN pralmorelin, is a synthetic hexapeptide ghrelin-receptor (GHSR) agonist and one of the oldest GH secretagogues. Originator work traces to Polygen (Germany)/Tulane University (USA); it was licensed to Kaken Pharmaceutical (Japan) and Wyeth (USA). It reached phase II clinical trials for GH deficiency and short stature but was never marketed for those indications. Its only approved use is in Japan, where it is marketed by Kaken Pharmaceutical as GHRP Kaken 100, a single-dose diagnostic agent for assessing growth hormone deficiency (first approved 22 Oct 2004). Everywhere else in 2026 it exists only as a research chemical / gray-market peptide, widely sold online as lyophilized vials. It is prohibited by WADA (listed as "GHRP-2 (pralmorelin)").

Sources: https://en.wikipedia.org/wiki/Pralmorelin (accessed 2026-09-20); https://synapse.patsnap.com/drug/35677c4f5278462b848a2ee6ae95a272; https://www.drugs.com/wada/s2-peptide-hormones-growth-factors-and-related-substances.html

Social standing — platform pulse

  • Instagram: Featured in the widely shared RIPD.FIT "Peptides for Muscle Gain Comparison Table" (Dec 2025) alongside ipamorelin, sermorelin, and GHRP-6 — listed with 100–300 mcg 1–2x/day on an empty stomach, 8–12 week cycles, best combo with CJC-1295 no DAC (https://www.instagram.com/p/DS73JZnEyNV/). An Aug 2026 educational reel states plainly "GHRP-2 is stronger" than GHRP-6 while contrasting their GH/cortisol/prolactin effects. Multiple vendor-branded educational carousels (Molecular Biotech, Sep 2026) frame GHRP-2/6/hexarelin as "old-school heavy hitters," with GHRP-2 positioned as the stronger, less appetite-driving sibling of GHRP-6.
  • Facebook Groups: Regularly discussed in GH peptide threads as the pairing partner for sermorelin/CJC-style GHRH analogs; community members advise fasted twice-daily dosing. The FB group "Peptide Community 101" is admin-run supplier spam ("verified supplier join the WhatsApp") — a scam-warning signal, not genuine discussion.
  • Threads: Mentioned within general GH-peptide comparisons; no standout standalone thread.
  • Group consensus: GHRP-2 is viewed as a legacy but legitimate secretagogue — more potent GH output than GHRP-6 with notably less hunger stimulation. It sits a tier below ipamorelin in current community favor because it raises cortisol and prolactin.
  • Viral moments: The RIPD.FIT comparison table (late 2025) is the highest-reach asset featuring GHRP-2, with heavy saves and repeated "DM for price lists" vendor replies in comments.
  • Main praise: Stronger GH pulse than GHRP-6; less appetite stimulation (better for cuts than GHRP-6); cheap and widely available as a research chem.
  • Main complaints: Raises cortisol and prolactin; legacy status — most educator content now steers buyers toward ipamorelin instead; persistent vendor spam around every mention.
  • Quotes: Creator in Aug 2026 reel: "GHRP-2 is stronger" (vs GHRP-6).

Social validation — Tier 1

Tier 1 — evidence across FB Groups (discussion threads), Instagram (owner/educator content: RIPD.FIT, Molecular Biotech, multiple reels), and general Threads coverage.

Named sources:

Key specs table

Spec Detail
Class Synthetic hexapeptide GHRP (growth hormone-releasing peptide)
Sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 (verified via Wikipedia, 2026-09-20)
Mechanism Ghrelin-receptor (GHSR-1a) agonist — NOT a GHRH analog
Half-life ~0.8 h (rat, preclinical); short-acting GH pulses in humans (source: archived ADIS R&D profile)
Route Subcutaneous (community); oral/IV/intranasal studied clinically
Community-reported dosing 100–300 mcg, 1–2x/day on empty stomach; 8–12 week cycles (RIPD.FIT table); commonly paired with a GHRH (CJC-1295 no DAC)
Molecular weight / CAS CAS 158827-34-0 (verified); MW ~818 Da — UNVERIFIED, not confirmed today
Diagnostic dosing (Japan) 100 μg IV single dose, fasted (GHRP Kaken 100 label)

Pricing

  • Approved-drug price: GHRP Kaken 100 is a Japan-only hospital diagnostic agent; retail price not collected 2026-09-20 — UNVERIFIED.
  • Research-chem price: Gray-market vial prices not collected 2026-09-20 — UNVERIFIED (community reports it as one of the cheaper GHRPs; no figures verified).
  • Compounded/clinic price: Not applicable — not a compounded-therapy item.
  • Marketplace range: No listings observed 2026-09-20 (FB Marketplace queries for peptides returned zero listings; sales happen off-platform).

What's included / what's needed

  • Research-chem listing: one lyophilized vial (common sizes 5 mg or 10 mg — UNVERIFIED exact current offerings).
  • What's needed alongside (factual, not instructions): bacteriostatic water for reconstitution, insulin syringes. (How-to reconstitution/dosing is not provided here.)

Support reality

  • Pharma support: None applicable outside Japan; GHRP Kaken 100 is a hospital diagnostic product in Japan.
  • Research-chem COA practices: Vendors typically post third-party COAs (purity ≥98–99% claimed); quality varies by supplier and is not independently verified here.
  • Clinic support: None — no legitimate clinic prescribes GHRP-2 for therapy.

Regulatory & safety status

Plain statement: Research chemical not for human use outside Japan; in Japan it is a single-dose diagnostic drug, not a therapy. Never FDA- or EMA-approved. WADA-prohibited at all times (S2.2.4, listed as GHRP-2 (pralmorelin)). Safety signals from literature: dose-dependent GH release with modest increases in prolactin, ACTH, and cortisol (Arvat et al. 1997); hunger stimulation (weaker than GHRP-6); transient warmth/flushing reported in clinical testing. Chronic-use desensitization data specific to GHRP-2 — UNVERIFIED.

Community verdict

GHRP-2 is treated as a legitimate legacy secretagogue — respected for its potency edge over GHRP-6 and lower appetite effect, but largely passed over in 2026 content in favor of ipamorelin, which avoids the cortisol/prolactin baggage. It survives mainly in comparison tables and as a budget stack option paired with a GHRH.

Image log

Open questions / UNVERIFIED

  • Exact current gray-market price per vial for GHRP-2 (not collected).
  • Molecular weight ~818 Da (plausible, not verified today).
  • Whether chronic GHRP-2 use desensitizes GH response to the same degree documented for hexarelin (~50–75%).
  • GHRP Kaken 100 retail/hospital price in Japan.
  • Claim seen in creator content that GHRP-2 "increases cAMP" while GHRP-6 "decreases cAMP" (Sept 2025 infographic) — mechanistic detail not verified.

Not medical advice. This file is research documentation only; nothing here is a recommendation to use any compound.

GHRP-2 (Pralmorelin) — hero view
hero view Original vendor page URL not recorded in research dossier
GHRP-2 (Pralmorelin) — hero view
hero view Original vendor page URL not recorded in research dossier
GHRP-2 (Pralmorelin) — hero view
hero view Original vendor page URL not recorded in research dossier
GHRP-2 (Pralmorelin) — hero view
hero view Original vendor page URL not recorded in research dossier

Sources