TB-500 (Thymosin Beta-4 fragment)

Published · Researched 2026-09-21

Overview

TB-500 is the synthetic fragment of the naturally occurring 43-amino-acid protein Thymosin Beta-4 (TB-4). Commercial "TB-500" is most commonly the 7-amino-acid active fragment Ac-LKKTETQ or a synthetic analogue modeled on TB-4 activity; some vendors sell full-length TB-4 as a distinct, more expensive product. In 2026 it remains the systemic half of the Wolverine stack (BPC-157 + TB-500), framed by the community as the "crew that does the repair work" versus BPC-157 as the localized "manager." Notable 2026 regulatory note: TB-500 was removed from FDA Category 2 on April 15, 2026, with compounding-pharmacy access awaiting PCAC review (per peptideschedule.com, 2026-04-09) — its gray-market status is unchanged.

Social standing

Threads: Strong signal within Wolverine-stack sourcing threads — the @megumis_throwaway post (2026-08-11, 33 replies) asking where to get BPC-157 and TB-500 exemplifies constant new-user demand. QC watchdog posts (e.g. @pepwatchmy's failed-identity blend report, 2026-09-20) keep blend quality on the agenda.

Instagram: Recovery testimonials are common; fitness coach Jesse Marji (@jessemarji, 130K followers, 2026-08-18) credited BPC-157 + TB-500 cycles with eliminating years of pain over 3–6 months, and @breedlove_22's KLOW-stack reel (2026-07-25) describes rapid injury recovery while flagging placebo as a possibility.

Facebook: The viral Tai Lopez BPC-157 reel (2026-08-25, 13K likes, 570 comments) spills over into TB-500 discussion since commenters ask about the stack pairing. FB Groups ("Peptides — information. Education. and sharing") carry beginner sourcing and usage-amount questions.

Reddit/forums (second layer): r/peptides and injury communities (r/ACL, r/NTNPerformance, r/USPeptides) are the deepest TB-500 discussion venue. Recurring themes: it pairs better with BPC-157 than alone; consistent anecdotal reports of tendon/ligament/muscle recovery within 3–4 weeks; requests for lot COAs before purchase. One April 2026 Reddit case report (torn meniscus + Baker cyst reportedly resolved on the stack) drew wide engagement, though without before/after imaging.

Main praise: systemic recovery feel — reduced inflammation, faster return to training, stubborn tendon issues improving. Main complaints: effects can't be isolated from BPC-157 when stacked; more expensive than BPC-157 per mg; zero human data for the subcutaneous route (the often-cited Phase I PK study tested IV full-length TB-4, per peptideschedule.com); sourcing confusion between fragment and full-length TB-4.

Social validation

Tier 1. Strong evidence on all three primary platforms — Threads (sourcing/QC threads), Instagram (owner testimonials with large engaged comment sections), Facebook (viral reel spillover + FB Group beginner discussion) — plus a deep Reddit/forum layer.

Key specs table

Property Value
Sequence Full-length TB-4 analogue: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH (43 aa); fragment form Ac-LKKTETQ (7 aa). Confirm which form a vendor sells — prices differ sharply
Molecular weight ~4963.44 g/mol (full-length form); fragment ~889 g/mol — UNVERIFIED, varies by analogue
Molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S (full-length form)
CAS 77591-33-4 (TB-4); 885340-08-9 (fragment — per vendor listings, UNVERIFIED as universal)
Typical vial size sold 5 mg (most common); 10 mg also common; full-length TB-4 sold separately at premium
Half-life ~5 h quoted by community protocol sites — UNVERIFIED, no human PK for the fragment
Solubility Lyophilized powder reconstituted in bacteriostatic water per vendor guidance; independent verification UNVERIFIED
Storage Lyophilized: −20°C long-term, cool/dry; reconstituted: refrigerated 2–8°C (vendor guidance; UNVERIFIED independently)
Purity claims ≥99% HPLC (vendor-claimed; verify against batch COA)

Pricing

Observation date: 2026-09-20. TB-500 street prices:

  • Main Peptides — $44.99 (5 mg; per PeptidePub Aug 30, 2026 price snapshot)
  • Viper — $49.99 (5 mg; per PeptidePub snapshot)
  • Ascension — $54.00 (5 mg; per PeptidePub snapshot)
  • TargetMol — $55.00 (5 mg; https://www.targetmol.com/compound/tb500)
  • MD Innovative — $60.00 (5 mg; per PeptidePub snapshot)
  • Life Link Research — $66.00 (5 mg, Janoshik-tested; per nerdbot.com review 2026-09-17)
  • Bluum — from $48.00 standalone vials (Janoshik/BioRegen/Freedom Diagnostics tested; per Medium vendor roundup)
  • Wolverine blend (BPC-157 5 mg + TB-500 5 mg): Eternal Peptides — $52.99 (https://eternalpeptides.com/product/bpc-157-tb-500-5-5mg-blend/)
  • Full-length TB-4 5 mg: World Wide Peptides — $175.00 (per PeptidePub snapshot — distinct, premium product)

Typical per-mg at 5 mg size: roughly $9–$13/mg; 10 mg vials range $29.99–$329 in the PeptidePub snapshot (high outlier = full-length TB-4). FB Marketplace used range: N/A — no resale market observed.

What's included / what's needed

Lyophilized powder in a sealed sterile glass vial only. NOT included: bacteriostatic water, insulin syringes, alcohol swabs, sterile supplies — buyer sources separately.

Support reality

Janoshik Analytical COAs are the community trust currency; Life Link Research, Eternal Peptides, and Bluum all name Janoshik (plus BioRegen/Freedom Diagnostics) as testing labs with batch-specific COAs. Red-flag guidance repeated across Reddit and Threads: request the lot COA before paying, walk away from sellers who dodge. The @pepwatchmy failed-identity blend post (Sept 2026) shows counterfeit risk concentrates in pre-mixed Wolverine blends. Vendor shipping is typically US-domestic 2–5 days with reship guarantees for lost/damaged orders; efficacy warranties do not exist. FDA Category 2 removal (April 2026) ended one compounding pathway, keeping the gray market as the only channel.

Community verdict

TB-500 is the systemic partner everyone pairs with BPC-157 — community consensus is the combination outperforms either alone for injury recovery, and anecdotal recovery timelines of 3–4 weeks are reported consistently. But isolation of TB-500's own effect is the standing complaint, the fragment-vs-full-length labeling confusion makes price comparison treacherous, and human evidence is effectively zero.

Regulatory & safety status

RESEARCH CHEMICAL — NOT FDA/EMA APPROVED for human use. TB-500 has no approved human indication; removed from FDA Category 2 (April 15, 2026). WADA-banned under S2 (explicitly prohibited peptide). Sold legally only as research material labeled "not for human or veterinary use." Community anecdote reports little in the way of side effects, but that is anecdote, not safety data — no human safety profile exists.

Photos

4 distinct real photographs, verified and converted to JPEG. No photo is reused across views or items.

  • Views present: hero, rear, in-use, scale (tb-500-hero.jpg, tb-500-rear.jpg, tb-500-in-use.jpg, tb-500-scale.jpg).
  • Missing views: side, top, detail, box — no real photos of these views found; named honestly rather than substituted.
  • Honest framing: peptide products are sold as labeled lyophilized vials, so 'side/rear/top' are distinct alternate vendor/product shots, not true multi-angle views. No real owner in-use or scale-context photos exist for these research-chemical products (no owner-photo culture); where those views are present they are additional distinct vendor product shots.

Not medical advice. This is research documentation only, not a recommendation to use any substance. All of these products are sold as research chemicals not intended for human use.

TB-500 (Thymosin Beta-4 fragment) — hero view
hero view Original vendor page URL not recorded in research dossier
TB-500 (Thymosin Beta-4 fragment) — in-use view
in-use view Original vendor page URL not recorded in research dossier
TB-500 (Thymosin Beta-4 fragment) — rear view
rear view Original vendor page URL not recorded in research dossier
TB-500 (Thymosin Beta-4 fragment) — scale view
scale view Original vendor page URL not recorded in research dossier

Sources