SHLP-6 (Small Humanin-Like Peptide 6)
Published · Researched 2026-09-21
Overview
SHLP-6 (Small Humanin-Like Peptide 6) is a mitochondrial-derived peptide (MDP) — a biologically active microprotein encoded within the mitochondrial 16S ribosomal RNA gene (MT-RNR2). It is one of eight known mitochondrial-derived peptides (humanin, MOTS-c, and SHLP1–6). Unlike its siblings SHLP-2 and SHLP-3, which are cytoprotective, SHLP-6 is notably pro-apoptotic: it has been shown in vitro to increase apoptosis in insulinoma (NIT-1) and human prostate cancer (22Rv1) cell lines, making it a tool for oncology and metabolic-disease research rather than a consumer longevity product. Current status in 2026: laboratory reagent only, sold by research biochemical suppliers.
Social standing
- Threads: No SHLP-6-specific owner or practitioner discussion found. Threads searches returned only generic peptide-supplier and lab-panel posts with no SHLP-6 content.
- Instagram/Facebook: No owner posts, reels, or group discussion found. The two accessible FB peptide groups returned zero SHLP-6 posts; no relevant Marketplace listings exist.
- Web: Presence is confined to reagent datasheets — AnaSpec (AS-65591), Biorbyt (orb2663353), MedChemExpress via Biozol (HY-P10625) — and wholesale/SEO vendor pages (e.g. arizona-mall.com) describing its mitochondrial signaling role.
- Recurring praise: essentially none in consumer channels; in research-supplier copy it is framed as a key tool for studying mitochondrial quality control, apoptosis signaling, and mito-nuclear crosstalk.
- Recurring complaints/failure modes: not applicable — there is no consumer user base to complain. The honest signal is absence: SHLP-6 has not crossed from lab reagent to biohacker staple, unlike MOTS-c and humanin.
Social validation
Tier 3 — weak validation, flagged. Single-platform only (research-supplier web datasheets); no Facebook Groups, Instagram owner content, or Threads discussion found. Included for comparison as a genuine mitochondrial-derived peptide, but with low community signal — it functions in this track as the lab-reagent reference point, not a community-validated pick.
Key specs table
| Spec | Value |
|---|---|
| Sequence (1-letter) | MLDQDIPMVQPLLKVRLFND (20 aa) |
| Sequence (3-letter) | NH2-Met-Leu-Asp-Gln-Asp-Ile-Pro-Met-Val-Gln-Pro-Leu-Leu-Lys-Val-Arg-Leu-Phe-Asn-Asp-COOH |
| Molecular weight | 2385.84–2386 Da |
| Molecular formula | C107H177N27O30S per Biorbyt; C107H177N27O30S2 per Biozol/MCE — UNVERIFIED which is correct |
| CAS | 368431-25-8 |
| Form | Lyophilized powder, unconjugated |
| Purity (supplier-claimed) | ≥95% by HPLC peak area |
| Storage | -20 °C; ships ambient (per Labscoop); 12-month expiry from receipt (Biorbyt) |
| Encoding gene | MT-RNR2 (mitochondrial 16S rRNA) |
| Known activity | Pro-apoptotic in vitro (pancreatic/prostate cancer cell lines); UNVERIFIED in humans |
Pricing
Observed 2026-09-20. Lab-reagent pricing only — no biohacker-vendor pricing found.
- AnaSpec AS-65591: $389.00 / 1 mg (in stock)
- Labscoop (AnaSpec AS-65591): $342.00/mg
- Biozol/MedChemExpress HY-P10625: price on request
- Facebook Marketplace used range: none observed (irrelevant listings only)
What's included / what's needed
Included: lyophilized reagent vial (1 mg typical). Needed: laboratory handling — analytical-grade solvents, -20 °C storage, standard peptide-lab practice. Not packaged or positioned for any non-laboratory use.
Support reality
Standard research-reagent support from lab suppliers (AnaSpec, Biorbyt, MCE distributors). No consumer-facing support, no COA-for-biohacker culture — buyers are assumed to be laboratories.
Regulatory & safety status
Laboratory research chemical only. Not FDA-approved, not EMA-approved, not sold for human use. It is a pro-apoptotic research tool; nothing about its profile suggests consumer use, and no community is using it that way.
Community verdict
SHLP-6 barely registers as a community peptide at all — it lives in catalogs, not in protocols. Its value in this track is as the honest contrast: a real mitochondrial-derived peptide whose entire footprint is preclinical, showing how far the social signal drops once you leave MOTS-c/humanin territory.
Not medical advice. This is a research summary only; SHLP-6 is a laboratory reagent not intended for human use.
Images
No images on file — the two previously downloaded vendor photos (hero, profile) were removed during identity review, and all 8 views (hero, profile, rear, top, detail, in-use, scale, box) are missing. No genuine traceable photos found; not substituted.
Named sources
- Biozol — - **Web:** Presence is confined to reagent datasheets — AnaSpec (AS-65591), Biorbyt (orb2663353), MedChemExpress via Biozol (HY-P10625) — and wholesale/SEO vendor pages (e.g.…
- Biorbyt — | Molecular formula | C107H177N27O30S per Biorbyt; C107H177N27O30S2 per Biozol/MCE — **UNVERIFIED which is correct** |
- MCE — | Molecular formula | C107H177N27O30S per Biorbyt; C107H177N27O30S2 per Biozol/MCE — **UNVERIFIED which is correct** |
- Labscoop — | Storage | -20 °C; ships ambient (per Labscoop); 12-month expiry from receipt (Biorbyt) |
- AnaSpec — reagent datasheet AS-65591
Source URLs were not recorded for these references.