SLU-PP-332

Published · Researched 2026-09-21

Item-list note: SLU-PP-332 replaces SHLP-2 in this category per the item-list rule. SHLP-2 (small humanin-like peptide 2) showed zero social pulse — no Threads hits, no Facebook group hits, and only a 2023 mouse-research news article (archyde.com) on the web. It failed the two-independent-social-source bar. SLU-PP-332 has an active 2026 biohacking discussion (see §3).

1. Overview

• Maker: No pharmaceutical maker — SLU-PP-332 originated as a research tool compound (Saint Louis University "SLU" series) and is sold only by research-chemical vendors (Alpha Omega Peptide, AminoCore, Beyond Peptides, SwissChems, Peptive, lab suppliers via Fisher Scientific/MedChemExpress and Tebubio).
• Purpose: Marketed in the biohacking scene as an "exercise mimetic" / "exercise in a pill" — an estrogen-related receptor (ERRα/β/γ) pan-agonist studied for mitochondrial biogenesis, fat oxidation, and endurance. Important: despite being sold alongside peptides, SLU-PP-332 is a small molecule, not a peptide (vendors list molecular formulas, not amino-acid sequences).
• Current 2026 version: Sold as oral capsules/tablets (250 mcg, 500 mcg, 1 mg, 20 mg, 100 mg strengths) and occasionally as injectable lyophilized powder. No human trials exist; all efficacy data is preclinical (mice).

2. Social standing

• Platform pulse: Strong and growing through 2026 — one of the most-discussed "metabolic" research compounds in biohacking circles. Called "exercise in a pill" across Threads, Reddit, and forums.
• Facebook group consensus: No hits in the Facebook groups searched via facebook-cli (Sept 2026) — its community lives on Threads, Reddit, and bodybuilding forums.
• Viral moments: Threads explainer by verified IFBB Pro Justin O'Donnell (@justinyodonnell, Oct 2025): "SLU-PP-332 is being called 'exercise in a pill.' But what's it actually doing inside your cells? Let's break it down." (11 likes, 12 replies). Threads buyer-request post by @muhdsuhairy7 (July 2026): "guys any seller reta or Slupp 332. drop your price please." (13 likes, 70 replies — high engagement for a sourcing ask).
• Praise: Users report energy/euphoria 2–3 h post-dose, thermogenesis, better cardio, gym sweat; one vendor-published n=1 (Marcus Thornton, Calgary — treat as marketing-adjacent) claimed −12 lbs over 8 weeks and RHR down ~8 bpm on 0.5 mg injectable 2×/day. A practitioner newsletter (Beyond The Trinity, marlonjperalta.substack.com, Issue 5) describes client use with fat-loss effects and draws the 1 mg vs 100 mg dosing debate. Retatrutide+SLU-PP-332 "dual-action" stack guides circulate (steroidwiki).
• Complaints: Heavy skepticism about oral bioavailability — "dose chaos" from 250 mcg to 100+ mg for the "same" product; many null reports at microgram oral doses; side reports of sleep disruption, wired-tired crashes, headache, overheating. Professional Muscle thread verdict from experienced users: "not worth the cash with minimal results," "sounded good on paper, doesn't translate." A GitHub research briefing (projectmastracc) concludes forum energy is "a function of marketing + hype, not of a superior published oral molecule" and rates all human claims speculative.
• Verified quotes (paraphrased, attributed):
  • @justinyodonnell (verified IFBB Pro, Threads, Oct 2025): framed SLU-PP-332 as "exercise in a pill" and broke down its cellular mechanism — platform: Threads.
  • @muhdsuhairy7 (Threads, July 2026): sourcing request for "reta or Slupp 332" drew 70 replies — platform: Threads.
  • Professional Muscle member: "I coverted my powder as an injectable... I agree with this....not worth the cash with minimal results" — platform: professionamuscle.com.
  • Professional Muscle member: "has anyone actually run slu-pp-332 at large amounts in mg? Like 20 or 40mg? Or have you all just used the 250mcg tabs?" — platform: professionamuscle.com (illustrates dose chaos).
  • Slideshare-compiled Reddit reviews: "Used 200 every morning for 2 weeks, lost about 3kg but I felt terribly tired all the time" / "I have taken 200mcg feel a small spike in energy." — via slideshare.net compilation (secondary; treat cautiously).
  • Beyond The Trinity newsletter: "The fat loss effect is absolutely real and well-documented" (in mice) — "all data is preclinical. Mouse models. No published human trials exist as of early 2026." — platform: Substack.

3. Social validation — Tier 3 (weak; strongest signal on non-contract platforms)

• Tier 3 — flagged as weak. Among the contract's three qualifying layers (Facebook Groups, Instagram owner content, Threads), only Threads showed owner/creator discussion, and no Facebook Groups signal was found. Its strongest real signal is off-contract (a dedicated Reddit subreddit, peptide forums, practitioner Substack) — substantial community, but on platforms the contract doesn't tier, so Tier 3 is the honest ceiling.
• Named sources and what each proves:
  1. Threads — @justinyodonnell (verified IFBB Pro) explainer + @muhdsuhairy7 high-engagement sourcing thread — proves 2026 creator and buyer discussion.
  2. r/SLUPP332 subreddit (dedicated subreddit, referenced in GitHub briefing landscape table) — proves a standing user community.
  3. professionamuscle.com "Slu-pp-332, 5amino 1mq, tesofensine" thread — proves experienced-user debate incl. negative verdicts.
  4. marlonjperalta.substack.com "Beyond The Trinity" Issue 5 — proves practitioner-level coverage with client anecdotes and literature review.
  5. steroidwiki.com Retatrutide + SLU-PP-332 stack guide — proves integration into community stacking culture.
  6. github.com/projectmastracc briefing — proves independent skeptical synthesis of the forum evidence landscape.

4. Key specs table

5. Pricing (dated 2026-09-20)

• Current MSRP (brand): None — research chemical only, no approved product.
• Street price (research vendors, observed Sept 2026): AminoCore 250 mcg × 60 caps $129.99; Beyond Peptides tablets from $99.99; Etsy (Objetouve) 1000 mcg caps $56+; Peptive (UAE) 250 mcg × 60 caps Dhs 699–799 (~$190–218 USD); Alpha Omega Peptide 500 mcg/1 mg/20 mg × 100 caps (bulk tiers $138.60–$146.30 shown); lab-grade powder 25 mg $178.50 (Fisher Scientific/MedChemExpress); 50 mg €322 (Tebubio/Focus Biomolecules). Oral-consumer range roughly $56–$220 per bottle.
• Marketplace used range: None observed.

6. What is included / what else is needed

• Oral: Bottle of capsules/tablets — nothing else needed. (No reconstitution.)
• Injectable powder (if encountered): Lyophilized powder vial — requires bacteriostatic water, insulin syringes, alcohol swabs. Research chemical not for human use.

7. Support reality

• Vendors: Research-chemical sellers; several advertise COAs and third-party testing (Alpha Omega Peptide, AminoCore, Beyond Peptides). Quality is unverified lot-to-lot; community authenticity disputes exist (esp. ultra-cheap oral tablets). No meaningful warranty/returns; assume no recourse.
• Red flags: Marketing copy on several vendor pages misdescribes it as a "peptide" with "amino acid sequence" language — it is a small molecule. Treat such vendors' scientific claims skeptically.

8. Community verdict

SLU-PP-332 is 2026's favorite exercise-mimetic story: the mouse data is genuinely striking and the "exercise in a pill" framing travels well on Threads and Reddit. But the experienced-user consensus is sobering — oral bioavailability looks poor, the effective human dose is unknown, microgram capsules are likely underdosed theater, and even enthusiasts hedge every claim as speculative. Interesting research story; unproven human compound.

9. Regulatory & safety status

• Research chemical — NOT FDA/EMA approved, NOT for human use. No human safety data exists. Sold "for research use only" / "not for human consumption" (labels verified on product photos).
• Known safety signals: No human trials, so no established safety profile. Community-reported: sleep disruption/early waking, wired-tired crashes, headache, lightheadedness, overheating, fatigue at some doses. Long-term effects entirely unknown. The related exercise-mimetic class carries historical baggage (Cardarine/GW501516 cancer signals in animals) — a different mechanism, but the reason human data matters.

10. Missing-image views + UNVERIFIED points log

• Images found (6/8): hero (Alpha & Omega 500 mcg capsule bottle), side (Sharps/DrKConrad 250 mcg × 60 bottle), detail (Etsy "Purity&Precision" 1000 mcg bottle), scale (SwissChems 100 mg × 60 bottle with visible capsules), rear-substitute (Peak Lab Peptides 5 mg vial, vendor photo), top-substitute (PepTique Labs 5 mg vial, vendor photo). All vendor product shots. Missing as genuine views: rear, top (both filed with honest substitute labels), owner-in-use, box/accessories.
• UNVERIFIED:
  1. Human pharmacokinetics / half-life — no data exists.
  2. Effective human dose — community range spans 400×; no basis to pick one.
  3. Oral bioavailability — widely doubted, unmeasured.
  4. Molecular formula conflict: AminoCore lists C21H21F3N2O4; Tebubio and SwissChems label show C18H14N2O2 — vendors disagree; true structure UNVERIFIED from fetched sources.
  5. All human efficacy/side-effect anecdotes — n=1s, uncontrolled, authenticity-contested.
  6. Vendor purity/COA claims — advertised, not independently verified.

Not medical advice. This is research material only; consult a qualified clinician.

Named sources

• Threads — @justinyodonnell (verified IFBB Pro) explainer + @muhdsuhairy7 high-engagement sourcing thread — proves 2026 creator and buyer discussion.
• r/SLUPP332 subreddit (dedicated subreddit, referenced in GitHub briefing landscape table) — proves a standing user community.
• professionamuscle.com "Slu-pp-332, 5amino 1mq, tesofensine" thread — proves experienced-user debate incl. negative verdicts.
• marlonjperalta.substack.com "Beyond The Trinity" Issue 5 — proves practitioner-level coverage with client anecdotes and literature review.
• steroidwiki.com Retatrutide + SLU-PP-332 stack guide — proves integration into community stacking culture.
• github.com/projectmastracc briefing — proves independent skeptical synthesis of the forum evidence landscape.
• Fisher Scientific/MedChemExpress listing — Mechanism: Pan-ERR (estrogen-related receptor α/β/γ) agonist; EC50 98 / 230 / 430 nM (α/β/γ).
• Tebubio — Mechanism: Pan-ERR (estrogen-related receptor α/β/γ) agonist; EC50 98 / 230 / 430 nM (α/β/γ).
• Forums — Dosing schedule: No established dose.
• Substack — Dosing schedule: No established dose.
• Substack literature review — Trial phase: Preclinical only — no published human trials as of early 2026
• Substack citing primary studies — Measured efficacy: Mice (metabolic syndrome model): ~12% lower body weight, ~10-fold less fat gain over 28 days, ~2.5× mitochondrial DNA in muscle, +70% treadmill endurance / +45% distance with no training
• Threads @justinyodonnell — Threads explainer by verified IFBB Pro Justin O'Donnell (@justinyodonnell, Oct 2025): "SLU-PP-332 is being called 'exercise in a pill.' But what's it actually doing inside your cells? (Oct 2025)
• Threads @muhdsuhairy7 — Threads buyer-request post by @muhdsuhairy7 (July 2026): "guys any seller reta or Slupp 332. (July 2026)
• slideshare.net — - Slideshare-compiled Reddit reviews: "Used 200 every morning for 2 weeks, lost about 3kg but I felt terribly tired all the time" / "I have taken 200mcg feel a small spike in energy." — via slideshare.net compilation (secondary; treat cautiously).
• Slideshare-compiled Reddit review — - Slideshare-compiled Reddit reviews: "Used 200 every morning for 2 weeks, lost about 3kg but I felt terribly tired all the time" / "I have taken 200mcg feel a small spike in energy." — via slideshare.net compilation (secondary; treat cautiously).
• Beyond The Trinity newsletter — - Beyond The Trinity newsletter: "The fat loss effect is absolutely real and well-documented" (in mice) — "all data is preclinical.
• Fisher — - **Maker:** No pharmaceutical maker — SLU-PP-332 originated as a research tool compound (Saint Louis University "SLU" series) and is sold only by research-chemical vendors (Alpha…

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