Longevity & Mitochondrial — Category Comparisons
Published · Researched 2026-09-21
13-peptide deep-research comparison for the 106-peptide project. Individual reports live in this directory; image files in img/. All prices observed 2026-09-21; all claims evidence-tagged with UNVERIFIED where applicable.
Report index
| # | Peptide | File | Tier | Images | Street price (observed) |
|---|---|---|---|---|---|
| 1 | Epithalon | epithalon | 2 | 7 | ~$21–$55 / 10 mg vial |
| 2 | SS-31 / Elamipretide | ss-31 | 2 | 7 | ~$48–$140 / 10 mg vial |
| 3 | SHLP-6 | shlp-6 | 3 | 0 | ~$342–$389 / 1 mg (lab reagent) |
| 4 | FOXO4-DRI | foxo4-dri | 3 | 5 | ~$200–$535 / 10 mg |
| 5 | Vezugen | vezugen | 3 | 2 | ~$45–$101 (caps/vial) |
| 6 | Ovagen | ovagen | 3 | 2 | ~$57–$101 |
| 7 | Testoluten | testoluten | 3 | 4 | ~$55–$135 |
| 8 | Prostatilen | prostatilen | 3 | 3 | ~€35–€69 |
| 9 | MOTS-c | mots-c | 2 | 2 | ~$33–$60 / 10 mg |
| 10 | Humanin | humanin | 2 | 2 | ~$48–$191 |
| 11 | Epithalamin | epithalamin | 3 | 0 | ~€65–$299 (extract formats) |
| 12 | Endoluten | endoluten | 3 | 1 | ~$55–$210 |
| 13 | Cerluten | cerluten | 2 | 8 | ~€40–€110 / ~$55–$135 |
Specs head-to-head
| Peptide | Identity | Sequence / composition | MW | Regulatory class |
|---|---|---|---|---|
| Epithalon | Synthetic tetrapeptide | AEDG (Ala-Glu-Asp-Gly) | 390.35 | Research chemical; not FDA/EMA-approved |
| SS-31 / Elamipretide | Synthetic tetrapeptide | D-Arg-Dmt-Lys-Phe-NH2 | 639.8 | FDA-approved (Forzinity, accelerated 2025-09-19) for Barth syndrome only; EMA UNVERIFIED |
| SHLP-6 | Mitochondrial-derived peptide | MLDQDIPMVQPLLKVRLFND (20 aa) | ~2386 | Lab reagent only |
| FOXO4-DRI | Synthetic D-retro-inverso peptide | 46-aa D-form (see report) | 5358.06 | Research chemical; no human trials |
| Vezugen | Khavinson cytogen | KED (Lys-Glu-Asp) | 390.39 | Supplement / research chemical; not FDA/EMA-approved |
| Ovagen | Khavinson cytogen | EDL (Glu-Asp-Leu) | 375.38 | Supplement / research chemical; not FDA/EMA-approved |
| Testoluten | Khavinson natural complex A-13 | Testicular extract; no defined sequence | — | Supplement; not FDA/EMA-approved |
| Prostatilen | Russian pharma product | Bull-prostate polypeptides + glycine | — | Registered medicine in Russia/CIS; NOT FDA/EMA-approved |
| MOTS-c | Mitochondrial-derived peptide | MRWQEMGYIFPRKLR (16 aa) | ~2174 | Research chemical; not FDA/EMA-approved |
| Humanin | Mitochondrial-derived peptide | 24-aa sequence (see report) | 2687.2 | Research chemical; not FDA/EMA-approved |
| Epithalamin | Natural pineal extract | Bovine pineal complex; no defined sequence | — | Supplement; not FDA/EMA-approved |
| Endoluten | Khavinson natural complex A-8 | Pineal extract; no defined sequence | — | Supplement; not FDA/EMA-approved |
| Cerluten | Khavinson natural complex A-5 | Cortical extract; no defined sequence | — | Supplement; not FDA/EMA-approved |
Value-for-money
| Peptide | Street anchor | What you get | Verdict |
|---|---|---|---|
| MOTS-c | ~$33–$60/10 mg | Most-discussed MDP at entry-level vial pricing | Best value in the MDP set |
| Epithalon | ~$21–$55/10 mg | Cheapest defined-sequence peptide in the category | Best value for defined-chemistry longevity |
| Ovagen / Vezugen | ~$45–$101 | Defined tripeptides with capsule convenience | Reasonable bioregulator entry |
| Humanin | ~$48–$191 | Quiet MDP, wide price spread | Fair — shop the low end |
| Cerluten | ~€40–€110 / ~$55–$135 | Strongest social proof of the bioregulators | Fair for the line |
| SS-31 | ~$48–$140/10 mg | Real drug pedigree, demanding dosing | Expensive but differentiated |
| Prostatilen | ~€35–€69 | Actual registered medicine (Russia/CIS) | Best value per "real drug" — wrong jurisdiction |
| Testoluten / Endoluten | ~$55–$210 | Undefined extracts, premium pricing | Poor on chemical legibility per dollar |
| Epithalamin | ~€65–$299 | Extract priced above its synthetic child | Poor — confusion tax |
| SHLP-6 | ~$342–$389/1 mg | Lab reagent, no community use | Lab-only value |
| FOXO4-DRI | ~$200–$535/10 mg | Most expensive per mg in the category | Worst — mechanism alone doesn't justify it |
Social sentiment matrix
| Peptide | Threads | Facebook/FB groups | Forums/video | Sentiment | |
|---|---|---|---|---|---|
| Epithalon | Yes (educational, @drivenonesllc, @drpaulvin) | No matches in accessible groups | Some | YouTube long-form (2026) | Warm — storied, trusted |
| SS-31 | Yes (@peptidecourses, @sy524771, @drpaulvin) | No matches | Some | Peptide media post-FDA-approval | Serious — real drug, real side effects |
| MOTS-c | Yes (@natashainca rotation, @drpaulvin) | No matches | Some | glp1forum, rapamycin.news, YT deep dive | Enthusiastic but honest about burn |
| Humanin | Yes (@natashainca rotation) | No matches | Little | Vendor guides | Quiet respect |
| Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
| SHLP-6 | None | None | None | None | None — catalog only |
| FOXO4-DRI | Yes (@pep_scout, educational) | None | None | None | Curious — "zero human trials" honesty |
| Vezugen | None | None | Category-level only | Vendor/TikTok retail | Neutral — bought on system trust |
| Ovagen | None | None | Category-level only | Wholesale lists | Neutral |
| Testoluten | None | None | Category-level only | Men's-stack listings | Neutral — stack culture |
| Prostatilen | None | None | Little | Expat resellers | Niche-loyal (diaspora) |
| Epithalamin | Yes (@drpaulvin distinction) | None | Little | Mostly confusion with Epithalon | Confused — identity crisis |
| Endoluten | None | None | Category-level only | Multi-product listings | Prestige niche — system-derived |
Use-case fit and risk matrix
| Peptide | Fit | Evidence depth | Key risk | Risk level |
|---|---|---|---|---|
| Epithalon | Telomere/sleep/circadian longevity | Animal + debated observational | Thin human data | Medium |
| SS-31 | Mitochondrial membrane / Barth syndrome (Rx) | FDA-approval trials (narrow indication) | Injection-site reactions; grey-market quality | Medium–High (grey use) |
| MOTS-c | Metabolic / exercise-mimetic | Preclinical only | Injection burn; no human data | Medium–High |
| Humanin | Neuroprotection / cytoprotection | Preclinical only | No human data; subtle effects | Medium |
| SHLP-6 | Lab reagent / pro-apoptotic research | Preclinical only | Not a human-use peptide | High (as a human intervention) |
| FOXO4-DRI | Senolytic research | Preclinical only | Zero human data; p53 biology | High |
| Vezugen | Vascular/endothelial (Khavinson model) | Small Russian literature | Undefined efficacy; reseller variance | Medium |
| Ovagen | Liver/GI (Khavinson model) | Small Russian literature | Same as Vezugen | Medium |
| Testoluten | Male reproductive (Khavinson model) | Undefined composition | Animal-extract unknowns | Medium |
| Prostatilen | Prostatitis/BPH (Russia/CIS Rx) | Real clinical use in home market | Unapproved import; format friction | Low–Medium (where registered) |
| Epithalamin | Pineal (Khavinson-traditionalist) | Historical extract use | Mislabeling; undefined composition | Medium |
| Endoluten | Pineal/neuroendocrine (Khavinson model) | Vendor claims only | Premium price, no evidence | Medium |
| Cerluten | Brain/cognitive (Khavinson model) | Vendor claims + owner anecdotes | Supplement-tier evidence | Medium |
Headline takeaways
- SS-31 is the only FDA-approved peptide here (Forzinity, accelerated approval 2025-09-19, Barth syndrome) — and the only one with a real drug label. Everything else is grey market or supplement-tier.
- Prostatilen is the only other actual medicine — registered in Russia/CIS for decades — making this category unusually "real-drug adjacent" versus pure research chemicals.
- The mitochondrial-derived peptides (MOTS-c, Humanin, SHLP-6) are the science story: genuine discoveries with real mechanisms, but only preclinical data; MOTS-c carries the community, Humanin the quiet respect, SHLP-6 nothing at all.
- The Khavinson bioregulators (Vezugen, Ovagen, Testoluten, Epithalamin, Endoluten, Cerluten) are the belief-system story: a functioning multi-vendor market and a genuine Instagram/Threads owner community, with item-level evidence ranging from thin to nonexistent. Cerluten has the strongest social proof; Endoluten the highest price; Testoluten/Epithalamin/Endoluten the least defined chemistry.
- Epithalon vs. Epithalamin is the category's naming trap: synthetic AEDG peptide vs. natural pineal extract — routinely conflated by vendors, correctly distinguished by practitioner voices (@drpaulvin).
- FOXO4-DRI is the prestige outlier: the cleanest senolytic mechanism on paper, zero human trials, and the worst value per dollar in the category.
- No Facebook Marketplace presence was observed for any item — this category trades through vendor sites, resellers, and TikTok/Instagram storefronts, not peer-to-peer marketplaces.
- Value ranking: MOTS-c ≈ Epithalon (entry) > Humanin / Cerluten (fair) > SS-31 (expensive, differentiated) > Prostatilen (real drug, wrong jurisdiction) > bioregulator extracts (system trust) > SHLP-6 / FOXO4-DRI (lab-priced, no human use case).
Social-pulse summary
The category splits into three social worlds. (1) The mitochondrial peptides — MOTS-c, SS-31, Humanin — live on Threads (practitioner educators like @natashainca, @drpaulvin, @peptidecourses, @drivenonesllc), peptide forums (glp1forum, rapamycin.news, professionalmuscle), and YouTube deep dives; discussion is mechanistic, candid about side effects (MOTS-c's injection burn, SS-31's site reactions), and honest about the human-data gap. (2) The Khavinson bioregulators — Cerluten strongest, then the rest — live on Instagram (@peptid_n, @drzaino, @ekaterina_luckylife, @qisupplements) and Threads owner accounts, with vendor storefronts and TikTok Shop as the commercial layer; item-level English discussion is thin, and the community is the system, not the molecule. (3) The lab reagents — SHLP-6, FOXO4-DRI — barely exist socially; FOXO4-DRI gets curator-level educational posts, SHLP-6 gets nothing. Accessible Facebook peptide groups returned zero matches for every item searched (Epithalon, SS-31, MOTS-c, SHLP-6) — the highest-signal source in the contract yielded nothing here, which is itself a finding: this category's community lives on Threads/Instagram and vendor-adjacent channels, not in open Facebook groups. No engagement numbers, group sizes, or prices were invented anywhere in this research; all UNVERIFIED points are tagged in the individual reports.
Report index (files)
- cerluten — Khavinson brain bioregulator A-5 (Tier 2, 8 images)
- epithalon — Synthetic AEDG telomere peptide (Tier 2, 7 images)
- ss-31 — Elamipretide / Forzinity, FDA-approved for Barth syndrome (Tier 2, 7 images)
- shlp-6 — Mitochondrial-derived pro-apoptotic peptide, lab reagent (Tier 3, 0 images)
- foxo4-dri — D-retro-inverso senolytic (Tier 3, 5 images)
- vezugen — Khavinson vascular tripeptide KED (Tier 3, 2 images)
- ovagen — Khavinson liver tripeptide EDL (Tier 3, 2 images)
- testoluten — Khavinson testes complex A-13 (Tier 3, 4 images)
- prostatilen — Russian prostate peptide medicine (Tier 3, 3 images)
- mots-c — Mitochondrial-derived metabolic peptide (Tier 2, 2 images)
- humanin — Mitochondrial-derived cytoprotective peptide (Tier 2, 2 images)
- epithalamin — Natural pineal extract, not synthetic Epithalon (Tier 3, 0 images)
- endoluten — Khavinson pineal complex A-8 (Tier 3, 1 image)
Not medical advice. This file summarizes research reports only; nothing here is a recommendation to use any listed substance.
Named sources
- @drivenonesllc — | Epithalon | Yes (educational, @drivenonesllc, @drpaulvin) | No matches in accessible groups | Some | YouTube long-form (2026) | Warm — storied (2026)
- @drpaulvin — | Epithalon | Yes (educational, @drivenonesllc, @drpaulvin) | No matches in accessible groups | Some | YouTube long-form (2026) | Warm — storied (2026)
- @peptidecourses — | SS-31 | Yes (@peptidecourses, @sy524771, @drpaulvin) | No matches | Some | Peptide media post-FDA-approval | Serious — real drug
- @sy524771 — | SS-31 | Yes (@peptidecourses, @sy524771, @drpaulvin) | No matches | Some | Peptide media post-FDA-approval | Serious — real drug
- @natashainca — | MOTS-c | Yes (@natashainca rotation, @drpaulvin) | No matches | Some | glp1forum
- @zzengzxc — | Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
- @kaimuldina_00 — | Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
- @peptid_n — | Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
- @drzaino — | Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
- @qisupplements — | Cerluten | Yes (@zzengzxc, @kaimuldina_00) | 1 public reel | Strong (@peptid_n, @drzaino, @qisupplements) | — | Warm within bioregulator niche |
- @pep_scout — | FOXO4-DRI | Yes (@pep_scout, educational) | None | None | None | Curious — "zero human trials" honesty |
- Instagram @ekaterina_luckylife — then the rest — live on Instagram (@peptid_n, @drzaino, @ekaterina_luckylife, @qisupplements) and Threads owner accounts
Source URLs were not recorded for these references.